Although having too many blood cells may not sound serious, it can slow down the flow of blood, and although PV, or polycythemia vera is a somewhat rare form of cancer, it’s important to be able to recognize PV symptoms. Many of the symptoms of PV can be signs of other conditions, making the condition difficult to diagnose. These include general tiredness, itching, red coloring on the face and purple coloring on the feet and hands, blurry vision, headaches and sweating. An early sign of PV may be weight loss, for seemingly no reason. Symptoms often become more noticeable as PV worsens, and these can include blood clots, small cuts that bleed excessively, bleeding from the gums, swelling of the joints, and pain in the abdomen and bones. It’s also common to have an enlarged spleen and suffer from bleeding in the digestive tract.